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Genes Involved In Hereditary Cancer

Definitions:
What does APC gene do?, What happens in familial adenomatous polyposis?, MEN Type 2, Familial Adenomatous Polyposis, Retinoblastoma, Von Hippel-Lindau Syndrome gene mutation, Multiple Endocrine Neuroplasia, Hereditary Breast-Ovarian Cancer Syndrome, Hereditary Nonpolyposis Colon Cancer AKA Lynch Syndrome, Results of Von Hippel-Lindau Syndrome, What is mutated in hereditary nonpolyposis colon cancer?, Neurofibromatosis, Li-Fraumeni Syndrome, What do BRCA1/BRCA 2 genes do?, MEN Type 1 quiz builder , Another name for hereditary nonpolyposis colon cancer? dynamic quiz ,

Answers:
Mutations in BRCA1/BRCA2 tumor suppressor genes, Mutations in RB1, gene that encodes proteins that control cell cycle; sporadic 2, Instability in microsatellite regions - Replication Error positive phenoty distant learning , Predisposes to colorectal cancer; APC has mutations, a tumor supp gene, Mutations in NF1; Can%27t inhibit Ras signaling path; tumors of nervous system, Colon and endometrial cancer; sessile serrated adenomas, APC inactivates beta-catenin; mutated APC cannot inhibit beta-catenin, HIF1 not degraded by mutated VHL; vascularized tumors arise, Over-expression of genes regulated by beta-catenin *myc - proliferate, VHL gene mut; VHL contains ubiquitin ligase E3 which degrades HIF1, Tumor suppr genes encode proteins that repair DNA damage, Mutation in TP53 tumor supressor gene; breast, brain, leukemia, sarcomas, adrenl , MEN1 gene mutated; tumor suppressor that regulates cell proliferation, Tumors of endocrine glands; autosomal dominant, RET gene mutated; RTK; GOF mutation - persistant proliferative signl, MLH1 or MSH2 that do mismatch repair; now pt mutations increase,