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Paranteral dosage forms

1. The factors determining the selection of proper PH in opthalmic solutions are
chemicals used to kill microorganisms from inanimate objects, chemicals used to kill microorganisms, chemicals used to suppress the growth of microorganisms, chemicals used to kill microorganism from living tissues,
2. The optimal conditions for performing sterilization with ethylene oxide are
complete abscence of any microorganisms their spores or metabolite products, complete abscence of pyrogens, complete abscence of visible and sub-visible particles, mandatory requirement for parenteral products,
3. Type 1 ampule glass is
1*10 -3, 1*10 -5, 1*10 -6, 1*10 -2,
4. What test are used to control purity
Destruction of some living microorganisms but without their spores, process of removing dust and dirt, complete destruction of all living microorganisms and their spores from preparation, chemical or physical method for treatment of objects by which complete destruction only of pathogenic....,
5. Isohydricity (PH equal to that of blood serum) for injection dosage form is
160-170C - 1-2h, 40-50C - 3-10h, 115,1C - 10min, 121,5C - 15min,
6. Purity for injection dosage forms is
160-170C - 1-2h, 100C - 30min, 50-60C - 30min, 121,5C - 15min,
7. The oprtimal conditions for sterilization in a dry-heat oven are
160-170C - 1-2h, 100C - 30min, 40-50C - 3-10h, 121,5C - 15min,
8. Infusions according to Eur Ph are
membrane filtration, sterilization with ethylene oxide results history , steam sterilization, sterilization by ionizing radiation (γ rays),
9. Specify the standard term for storage of eye drops after the first opening
160-170C - 1-2h, 20-30%25 RH, 70-80C 1-2h, 40-80%25 RH, 40-50C 3-10h, 1,2 atm 121,5C 15min,
10. In which of the listed sterile preparations the use of buffers is not admissible
corpuscular radiation with β particles, γ-rays, gaseous plasma, sterilization in autoclave,
11. In which of the listed sterile solutions the use of buffers is admissible
soda-lime-silica glass with additional treatment of the inner surface with SO2, Borosicilate glass, soda-lime-silica glass without additional treatment of the inner surface with SO2, with very high hydrolytic resistance,
12. The biggest source of contamination with pyrogens is
sterilization in autoclave, microbial quality, cleaning of surfaces, air filtration,
13. Apyrogenicity for injection dosage forms is
water for injection, sterile 0,9%25 solution of sodium chloride, sterile isotonic solution of boric acid, cottonseed oil,
14. Which one of the sterilization methods and parameters is suitable for sterilization of oily solutions
0,9%25 solution of sodium chloride, liquid paraffin, peanut oil, glycerin,
15. Injection solution of which substances can be packed in ampoules glass -3rd hydrolytic class
by addition of NaCl glucose boric acid, by addition of tween span lecithin, by phosphate citrate or acetate buffers, by lyo- and cryoprotectants,
16. The main methods for sterilization with radiation are
injections, infusions class page , eye solutions, eye lotions,
17. The tolerance of the eye for PH changes is
injections, infusions quiz generator , eye solutions, injections for intraocular administration,
18. What does term isohydric solution mean
phosphate buffer, citrate buffer, acetate buffer, hepes buffer,
19. sterilization is
multidose IM solution with 20ml volume per single dose, multidose IV solution with 10ml volume per single dose, multidose intrathecal solution with 5ml volume per single dose interactive , multidose SC solution with 15ml volume per single dose,
20. Disinfectants are
Benzalkonium chloride, thimerosal, sodium metabisulphate, butylated hydrohyanisole,
21. Isotonicity for parenteral dosage forms is
substances which reach systemic circulation and cause vomiting nausea and diarrhea, substances which suppress the growth of microorganisms create online quizzes , alkylating agents create online activities , fever-producing organic substances arising from microbial contamination,
22. Water for injections is obtained by
DNA viruses, Gram %2b bacteria, Gram - bacteria, Fungi,
23. What units are used to express the concentration of electrolytes in infusion solutions and concentrates for hemodialysis
Mandatory requirement, Additional requirement, Other requirement, Not characteristic of parenteral dosage forms,
24. Sodium chloride is used as
mandatory requirement, Additional requirement dynamic quiz , other requirement , not characteristic of injection dosage forms,
25. The optimal conditions in the Koch%27s type apparatus during sterilization are
mandatory requirement, Additional requirement, other requirement , not characteristic of injection dosage forms,
26. The most commonly used viscosity increasing agents in eye preparations are
mandatory requirement, Additional requirement, other requirement , not characteristic of injection dosage forms,
27. What are mandatory characteristics of the package materials for parenteral solutions
mandatory requirement, Additional requirement, other requirement prepare quiz , not characteristic of injection dosage forms,
28. The optimal conditions according to Eur Ph in an autoclave during sterilization are
Direct inoculation of the culture media for 3-7 days, 37C temp - detecting growth of microorganisms, Biological test with rabbits, biological indicators test, limulus amebocyte lysate test,
29. The stabilizers used in eye solutions against hydrolysis are
Direct inoculation of the culture media for 3-7 days, 37C temp - detecting growth of microorganisms, Tests for validation of sterilization procedure - physical chemical and biological indicators, Biological test with rabbits, Clinical trials with people,
30. What are mandatory characteristics of the large volume solutions for infusion
Test for %27%27particulate contamination: sub-visible particles%27%27, test with filtration, Direct inoculation of the culture media for 3-7 days, 37C temp - detecting growth of microorganisms, Test for %27%27particulate contamination: visible particles%27%27,
31. The stabilizers used in eye solutions against oxidation are
sterility stability purity and apyrogenicity, sterility stability purity and isotonicity, sterility stability purity apyrogenicity and isotonicity, sterility stability purity apyrogenicity and isohydricity,
32. Limulus lysate test is used for detection of
sterility stability purity and apyrogenicity, sterility stability purity and isotonicity, sterility stability purity apyrogenicity and isotonicity create online tests , sterility stability purity apyrogenicity and isohydricity,
33. What does term isotonic solution mean
sterility stability purity and apyrogenicity, sterility stability purity and isotonicity, sterility stability purity apyrogenicity and isotonicity, sterility stability purity apyrogenicity and isohydricity,
34. How can PH be adjusted in injection solutions
chemical stability, transparency, low thermal stability, with high density,
35. the characteristics of ampulle glass type 2 are
steam sterilization-autoclaving, dry heat sterilization, pasteurization, sterilization in Kochs type apparatus,
36. Injection solution of which substances can be packed in ampoules glass -3rd hydrolytic class
Solution with the same osmotic pressure as specific body fluid blood plasma tears, solution with the same PH as specific body fluid blood plasma tears short answer questions , solution with the same viscosity as specific body fluid blood plasma tears, Solution with the same type and concentration of ions as specific body fluid blood plasma tears,
37. The characteristics of ampulle glass type 3 are
Solution with the same osmotic pressure as specific body fluid blood plasma tears, solution with the same PH as specific body fluid blood plasma tears, solution with the same viscosity as specific body fluid blood plasma tears, Solution with the same type and concentration of ions as specific body fluid blood plasma tears,
38. Preservatives used in eye preparations are
g/100ml %25, mEq/l, mOsmol/l, mg/ml,
39. What is the usage of Na2 - EDTA citric and tartaric acid in injection solutions
Is procedure employed to remove toxins from the blood, can be applied for acute and chronic kidney insufficiency, can be applied for heart and pulmonary failure, in invasive method,
40. What are mandatory characteristics of the concentrates for hemodialisis
Dialysis diffusion osmosis ultrafiltration, dialysis dissolution osmosis ultrafiltration, sterilization hydrolysis osmosis ultrafiltration tool for teachers , dialysis hydrolysis diffusion osmosis,
41. The characteristics of ampulle glass type 1 are
very high hydrolytic resistance, low hydrolytic resistance, borosicilate glass, soda lime silica glass,
42. Injection according to Eur Ph are
low hydrolytic resistance, high hydrolytic resistance, soda lime silica glass with a suitable treatment of the inner surface with SO2, soda lime silica glass without treatment of the inner surface,
43. methods for so-called cold-sterilization
moderate hydrolytic resistance, high hydrolytic resistance, soda lime silica glass with a suitable treatment of the inner surface with SO2, soda lime silica glass without treatment of the inner surface,
44. Hydrophilic vehicles for injections are
sterile solutions emulsions and suspensions, powders and gels for injections, eye inserts, implants,
45. Which of the following substances are allowed for use as preservatives in injection solutions
sterile aqueous solutions or emulsions O/W, sterile oil solutions and suspensions, isotonic with respect to blood, intended for administration in small volume,
46. The main methods for sterilization of parenteral preparation according to Eur Ph are
0,45 μm, 0,22 μm, 1,22 μm, 1,45 μm,
47. the water for injections must be
ethylcellulose, petroleum, methylcellulose, polyvinyl alcohol,
48. What are mandatory characteristics of the injection solutions
PH 3-10, PH 7-8, PH 6-9, PH 2-5,
49. Pyrogens are
the tolerance of the eye for PH changes, physico chemical properties and stability of an active substance, type of disperse system of a dosage form, the frequency of administration,
50. Limulus lysate test
tocopherol acetate, phenylmercuric acetate, acetylcysteineweb page, benzalkonium chloride,
51. What is the function of phenol nipagin and benzalkonium chloride in injection solutions
100C 30min-steam sterilization with Kochs sterilizer, 121,5C 15min - steam sterilization in autoclave, 160-170C 1-2h - dry heat sterilization, 210-230C 30min - dry heat sterilization,
52. Stability for injection dosage forms is
fungi, gramm - bacteria, endotoxins, viruses,
53. Aseptic processing can be apply when
is used for detection of endotoxins, is based on measurement of the body temp of rabbits, uses amebocytes of crab blood cells, do not interfere with any active substances,
54. The most commonly used buffer systems in formulation of sterile solutions are
pyrogens, gramm - bacteria, viruses, gramm %2b bacteria,
55. Bacterial membrane filtration removes
sterile, bacteriostatic, apyrogenic, isotonic,
56. According to Eur Ph %27%27sterility assurance level%27%27 (SAL) must be
Papaverin HCl, progesterone, sodium thiosulphate, procaine HCl,
57. B.Stearothermophilus is used in validation of
Urotropine, testosterone results , caffeine/sodium benzoate, glucose,
58. What are main processes/principles on which hemodialysis is based on
sodium chloride, ascorbic acid, sodium thiosulphate, meta-cresol,
59. The diameter of pores of filters for bacterial filtration must be
buffers, 0,1M solutions of HCl or NaOH, glucose, 0,9%25 solution of NaCl,
60. Hemodialysis
Kochs sterilizer - 100C 30min, Autoclave - 121,5C 15min language , Dry heat - 40-50C 1-2h, Ethylene oxide - 160-170C 3-10h,
61. What tests are used to control sterility
PH adjusting agent, isotonic agent, antioxidant, chemical stabilizer,
62. Specify the correct combination of temp regimen -time for the certain method of sterilization
by bacterial filtration, reverse osmosis, distillation, dialysis,
63. What tests are used to control apyrogenicity
Preservatives, buffers, isotonic agents, synergist of antioxidants,
64. Sterility is
preservatives, buffers online learning games , isotonic agents, synergist of antioxidants,
65. Non-aqueous vehicles for parenteral preparations are
three months, six months, 48h, four weeks,