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Modified release drug forms DT2 -ST

1. Quality control tests of the membrane drug delivery systems are
Decreazed number of intakes, Increased plasma drug concentration, Increased rate of absorption, Reduction of side effects,
2. The main wuality contol tests for hydrogel drug delivery systems are
Increased rate of drug absorption, Drug plasma concentration within the therapeutic window, Decreased number of intakes, Fast release of the active substances,
3. Liposomes are
With too short plasma half-life - less than 1 hour, With too long plasma half - life - more than 10 hours, With hig molecular wight, Very hydrophilic substance,
4. Polymers used for preparation of membrane systems witg modified release are
Controlling the drug dissolution process, Incorporation of soluble drug, Incorporation of surface active substances, Controlling the drug diffusion process through the matrix,
5. What is the structure of membrane drug delivery systems
Micellar solubilization , Use of slightly soluble salts, Use of polymers, Use of co-solvents,
6. Which excipients are used as pore-forming agents for preperation of porous matrix systems
Those with diffusion controlled drug release, Those with osmosis controlled drug release, Those with regulation of drug dissolution rate, Those in which the release of the drug is controlled by chemical process,
7. Porous matrix tablets could be prepared by
Reduction the specific surface area of the particles, Decreasing drug solubility by obtaining of less soluble salts, Changing in the diffusion area, Coating of the drug with polymeric insoluble film,
8. The purpose of liposomes are
Reducing the specific surface area of the particles, Decreasing drug solubility by obtaining of less soluble salts, Changing in the diffusion area, Coating of the drug with polymeric insoluble film,
9. Drug substance is chemical drug delivery systems is
Systems in which the drug is incorporated in solid matrix, Systems in which the drug or drug dosage form is coated with insoluble but permeable polmeric membrane which controls release of the drug, Systems in which the drug or drug dosage form is coated with soluble permeable polymeric membrane which does not control release of the drug, Systems with porous or non-porous memebrane,
10. Write the main steps in drug release process from hydrogel drug delivery sestems
The thickness of the membrane, The porosity of the membrane, The pore size, The ratio amorphous phase/crystal phase of the polymeric membrane,
11. Factors influencing drug release from monolithic systems are
The porosity of the membrane, The channels in the core, The amorphous phase of polymeric membrane, The crystal phase of polymeric membrane,
12. Polymers used for preparation of microspheres with modified release are
Low molecular wight excipients, Polymers insoluble in body fluids, Polymers soluble in body fluids, High molecular weight excipients,
13. Factors influencing drug release from hydrogel systems are
The thickness of the polymeric membrane, The membrane permeability, The elasticity of the polymeric membrane mix questions , The properties of the core,
14. The film-forming excipients used in preparation of the membrane drug delivery systems are
Disintegraton, Rate of drug release, Friability, Shape of the systems,
15. The advantages of liposomes are
Coating in coating pan, Coating in fluid-bad drier, Tableting after dry granulation, Tableting after wet granulation,
16. Polymers used for preperation of matrix systems with modified release are
Incorporation of pore-forming excipients, Crosslinking of the polymer, Method of synthesis of the polymer, The compression force,
17. For preperation of hydrogel systems are used
The porosity of the membrane, The tortuosity of pores and channels, The diffusion coefficient of the drug into the membrane, Degree of swelling of the membrane,
18. The monolithic drug delivery systems are
Monolithic ( matrix) systems, Osmotic pump systems, Membrane systems, Hydrocolloids and true hydrogel systems,
19. Write the main methods are used for preperation of liposomes
The natural of polymers, Molecular weight of polymer, The thickness of polymeric membrane, The diffusion coefficient of the drug into the membrane,
20. Biodegradable polymers are
Diffusion through free volumes, Diffusion through crystal phase of the polymer matching excercise , Swelling of the matrix,
21. Modified-release drug delivery systems characterize with :
Thickness of the membrane , Permeability of the gell, Degree of swealling of the polymer, Crystal phase of the polymer,
22. The main factors that influence drug release from membrane drug delivery systems are delivery systems with porous membrane
Diffusion through pores in the polymer, Diffusion through free volumes in the gel, Diffusion through the amorphous phase of the polymer membrane, Diffusion though the crystal phase of the polymer membrane,
23. Which are the main factors that influence the drug release from biodegradable systems
Non-swelling polymers, Non-permeable polymers, Slowly soluble in body fluids polymers, Swelling polymers,
24. Sustained drug release could be achieved by
Tablet production by direct compaction, Coating in fluid - bed drier, Coating pan, Tablet production via wet granulation,
25. Plasticizers added to the membrane systems can influence
The porosity of the membrane, The shape of pores and channels, The diffusion coefficient of the drug into the membrane, The swelling rate of the membrane,
26. For preparation of hydrogel systems are used
Disintegration, Rate of drug release, Friability web tool , Shape of the system,
27. Which are the main methods that are app;ied for preparation of microcapsules
Systems in which the drug is incorporated in solid matrix, Systems in which the drug or drug dosage form is coated with insoluble , but permeable polymeric membrane which controls release of the drug, Systems in which the drug or drug dosage form is coated with soluble permeable polymeric membrane which does not control release of the drug, Systems with porous or non- porous membrane,
28. Microcapsules are
Thickness of the membrane, Permeability of the polymer, The ratio of crystal to amorphous phase in the polymer, Type and the quality of plasticizer in the membrane,
29. Which are the possible mechanisms of interaction between liposomes and cells
Diffusion coefficient of the drug in the polymer, Permeability of the polymer, Flexibility of the membrane, prosity of the membrane,
30. Diodegradable systems are
Incorporation of the pore-forming excipients, Crosslinking of the polymer save time , Method of sysnthesis of polymer, The type of the plasticizer in membrane,
31. Polymers used for preparation of hydrogel systems with modified release are
System in which drug release is due to the chemical or biological (enzymatic) degradation of weak bonds of polymer chains, Membrane systems, Systems in which the drug or drug dosage form is coated with soluble permeable polymeric membrane which does not control release of the drug, Systems with porous and non-porous membrane,
32. Which factors can be used to control the dissolution of the drugs
The thickness of the polymer membrane, Water-solubility of drug, The chemical bonds in the polymer molecules, The molecular weight of the polymer,
33. What are the chemical systems with modified drug release
Hydrolyzable polymers, Polymers with low permeability, Soluble in body fluids polymers, Gastro-resistant polymers,
34. The main methods for preperation of the membrane drug delivery systems are
Tablet production by direct compaction, Extrusion, Coating in fluid-bed drier, Coating in coating pan,
35. Microspheres are
Water solubility of drug, Relative density of drug, Degradation rate of the polymer, Partioning coefficient (O/W),
36. Polymers used for preparation of biodegradable systems with modified release are
Rate and degree of hydrolysis of the polymer, Permeabolity of polymer membrane, Molecular weight of the polymer, n-heptane/water distibution coefficient,
37. In which type of matrix system drug release takes place mainly through the pores
System in which drug release is due to the chemical or biological ( enzymatic ) degradation of the weak bonds of polymer chains, Membrane systems crossword maker , Systems in which the drug or drug dosage form is coated with soluble permeable polymeric membrane which does not control release of the drug, System in which drug release is due to destruction of the system caused by chemical reaction in the site of action - the drug is chemically bonded with polymer,
38. Which of the drug substances are not suitable for incorporation in drug delivery systems with modified release
Drug and plasticizer, Drug and Drug quiz , Drug and polymer, Drug and another excipient,
39. Administration of modified drug delivery systems is characterized with
Included into polymer chain, Chemically bonded to functional groups of polymer, Chemically bonded to plasticizer, Chemically bonded to low molecular excipients,
40. Sustained drug release could be achieved by
Membrane systems, Monolithic systems, Micro-size systems, Nano-size systems,
41. Drug delivery systems with modified release are characterized with
Membrane systems, Monolithic systems, Micro-size systems, Nano-size systems,
42. Which are the main factors that influence the drug release from biodegradable systems
The size, The shape, The structure, The drug release mechanism,
43. The main characteristic of chemical drug delivery systems is that there are chemical bonds between
Moulding after solvent evaporation, Spray-drying, Coating in fluid-bed drier, Direct compression,
44. What are the main factors that could control the process of diffusion in modified drug delivery systems
Tablet production via wet granulation, Direct tableting, Coating in fluid-bed drier, Spray-drying,
45. In which type of matrix system drug release takes place mainly through a gel layer
Polyvinylpyrrolidone, Eudragit E crossword maker , Ethylcellulose, Eudragit RS,
46. Drug release form biodegradable systems is controllerd by
Starh, Ethylvinylacetate e-learning , Polyamide and polythylene, Polyvinylpyrrolidone,
47. In which types of matrix system drug release takes place mainly after matrix degradation
Sodium alfinate, Hydroxypropoyl methylcellulose interactive learning , Glycogen, Polyvinylpyrrolidone,
48. What are the main factors that influence drug release process from membrane drug delivery systems with non-porous membrane
Polylactic acid, Ethylcellulose, Polyvilylchloride, Polyglycolic acid,
49. Drug release from hydrogel drug delivery systems can be controlled by
starch, crossmarmellose invite students , Polylactic acid, Polyglycolic acid,
50. Drug release from membrane drug delivery systems with porous membrane depends on
Porous monolithic systems, Hydrogel systems, Biodegradable systems, Monolithic systems with dissolved/dispersed in the matrix drug,
51. Which are the main methods that are applied for preperation of micropheres
Porous monolithic systems, Hydrogel system, Biodegradable systems, Monolithic systems with dissolved/dispersed in the matrix drug,
52. What are the differences between microspheres and microcapsules
Porous monolithic systems, Hydrogel systems, Biodegradable systems ESL , Monolithic systems with dissolved/dispersed in the matrix drug,
53. Drug release from membrane drug delivery systems with non-porous membrane depends on
Small structures with concentated bilayered vesicles surrrounded by a phospholid membrane, colloidal systems, with sizes in the range 20-5000μm test , Stable systems,
54. The main quality control tests for hydrogel drug delivery systems are
To increase solubility of drug, To reduce side effects of drug, To improve dosage form stability, To achieve fast therapeutic effect,
55. In which type of matrix system drug release takes place mainly through a polymeric phase
Phospholipids, Starch, Cellulose, Cholesterol,
56. Polymers used in preparation of hydrogel drug delivery systems are
Endocytosis, Gene exhange, Osmosis, Membrane cell merging,
57. What are the main factors tha influence drug release process from membrane drug deliverys ystems with porous membrane
Porous monolithic system, Hydrogel systems matching excercise , Biodegradable systems, Monolithic systems with dissolved/dispersed in the matrix drug,
58. Drug release from monolithic drug delivery systems can be controlled by
Improved stability, Easy production, Biocompatibility, Targeting distribution in the organism,
59. Hydrogel drug delivery systems are
Direct compression, Granulation, Detergent dialysis, Film-method,
60. What are the main methods that are applied for preperation of biodegradable drug delivery systems
Coating method, Direct compression, Tablet production via wet granulation, Encapsulation,
61. Factors influencing drug release from monolithic systems are
Encapsulation, Tabletting, Lyophilization, Spray-drying,
62. Drug release from hydrogel drug delivery systems can be done by
Polyvinylpyrrolidone, hydroxypropyl ethylcellulose, Methylcellulose, Polylactides,
63. Which of the listed drug delivery systems are classified as physical systems
Gelatin, Starch, Carbopol, Polyvinylpyrrolidone,
64. The composition of liposomes includes
Sodium chloride , Celllulose, Pectin results , PEG,