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Granules DT2 - ST

1. Which from the listed excipients are binders ?
To improve flowability of active substance?, To increase the bulk volume of the powder mix ?, To ensure disintegration, To improve the taste,
2. What kinds of methods for granulation are used in the pharmaceutical industry ?
Dextrose, Lactose, Mannitol, Sucrose,
3. Which are the advantages of polyvinylpyrrolidone (PVP) as a binder ?
silicon dioxide, lactose, polyvinylpyrrolidone (PVP), mannitol,
4. what are the basic characteristics of the granules obtained by high shear mixer granulator?
silicon dioxide, lactose, polyvinylpyrrolidone (PVP), sodium starch glycolate,
5. Which of the listed examplesdescrubes the purpose of granulation agent ?
talk, lactose, microcrystalline cellulose, magnesium stearate,
6. Which technological process are carriedout during granulation in fluid bed dryer ?
stearic acid, talk, calcium hydrogen phosphate, sorbitol,
7. What kinds of methods are used for dry granulation ?
to improve flowability, to increase the mass for granulation, to ensure the agglomeration between powder particles, to improve the taste,
8. Which from the listed excipients are binders ?
inorganic salts, polymers, polyos language , stearates,
9. Which from the listed excipients are binders ?
lactose, polyvinylpyrrolidone ( povidone ), sorbitol, gelatin,
10. what kind of excipients determine the effervescent effect of the effervescent granules?
microcrystalline cellulose, starch solution ( starch mucilage ), mannitol, crosslinked polyvinylpyrrolidone,
11. What are the disadvantages of the drying process of granules?
talc, polyvinylpyrrolidone (povidone), sorbitolweb page, lactose,
12. What are the binders according to their chemical structure ?
starch solution (starch mucilage ), crosslinked polyvinylpyrrolidone, calcium phosphate, gelatin solution,
13. Which from the listed below excipients are diluents ?
ethylcellulose, methylcellulose, microcrystalline cellulose, cellulose acetate phthalate,
14. What kinds of granulator are used in pharmaceutical industry for wet granulation ?
gelatin, sodium starch glycolate, sorbitol, hydroxypropyl methylcellulose,
15. what kinds of apparatus are used for preperation of granules by dry granulation methods ?
slow granule disintegration, very good solubility in water, good flowability , fast granule dissolution,
16. what are the disadvantages of planetary kneading granulator ?
1-3%25, 5-10%25, 10-15%25, all mentioned above,
17. which are the advantages of dry granulation ?
the binder excipients, the liquid used for granulation, the cross-linked excipients, cellulose derivatives,
18. Which cellulose derivative is used as binder for dry granulation ?
extrusion, sieing, wet granulation, lyophilization,
19. Which one from the listed excipients is binders ?
extrusion, slugging, fluidize-bed granulation, roller compaction,
20. What is the basic function of binders ?
lactose, polyvinylpyrrolidone, microcrystalline cellulose, gelatin,
21. how microcrystalline cellulose (MCC) is included as a binder during granulation ?
lack of humidity, without drying stage ( suitable for thermolabine substances ), easily soluble granules can be obtained, granules with high porosity can be obtained,
22. What is the disintegration time for effervescent granules according to Eur.Ph?
granulation convective mixing, slugging, fluidized-bed granulation, roller compaction,
23. Which from the listed excipients are diluents ?
as solution ingranulating liquid, as water dispersion, as dry substance, all mentioned before,
24. Questionwhich of the listed methods are used for wet granulation?
compression, dry mixing, drying, sieving,
25. Which from the listed excipients are diluents ?
mixing with other excipients, slugging online quizzes , screening of wet mass, roller compaction,
26. What groups of excipients can be used for granulation ?
removing of the granulating liquid, increasing in solubility active teaching , ensure sufficient mechanical strangth of tablets, particle aggregation,
27. what are the basic characteristics of the granules obtained by fluid bed granulator?
stability of the product, disintegration of the product, compressibility online quizzes , the uniform distribution of active substance,
28. What are the mechanisms of solid bridges formation during wet granulation ?
up to 3 %25, up to 5 %25, up to 1%25, until coplete drying,
29. The size of the sieve for regranulation depends on
up to 8%25, up to 5%25, up to 1%25, until complete drying,
30. What are the particle bonding mechanisms in dry granulation ?
high humidity, destruction of thermolabile substances, Migration of active substances and excipients, All mentioned above,
31. What are the conditions for disintegration test for effervescent granules?
dynamic drying, static, convective drying, conductive drying, drying in fluid bed dryer,
32. which of the listed excipients can be used in dry granulation ?
Stability of the product, Dry mixing with the other excipients, Recovery of granules after drying printable , Classification of granules by particle size,
33. What are the methods for preperation of effervescent granules?
the composition of the granules, the type of binder, the purpose of aplication of granules, the concentration of binder,
34. What kinds of fillers are basically applicable for granules intended as a final drug product ?
between 1 - 2 mm, betwwen 0,5 - 1mm, between 2 - 3mm, larger than 3 mm,
35. The regranulation of granules used for producing of tablets is performed through sieve with the size
Attractive forces between solid particles, solid bridges formation, elastic deformation, electrostatic repulsion forces,
36. The optimal residual moisture into dried granule determines
crystallization, van der walls forces, electrostatic forces, all mentioned above,
37. What is the appropriate residual moisture that should be achieved after drying of granules which do not contain carbohydrates ?
deformation, crystallization, solid bridges formation, fracturing,
38. What is the aim of technological process regranulation ( calibration )
roller compacter, planetary mixer, fluidizer-bed granulator, v-shaped granulator,
39. What is the appropriate residual moisture that should be achieved after drying of granules containg carbohydrates?
high granule porosity, slow process, perform only one operation, difficult to define the end of the process,
40. What are the particle bonding mechanisms in wet granulation ?
roller compacter, high-shear mixer granulator, extruder, tablet press and mills,
41. What is the basic function of fillers ( diluents )
high porosity granules, low hardless, dense granules, high hardness,
42. The instergranular migration during drying of granules can be observed in
high porosity, high hardlness, dense granules, low hardless,
43. Which of the listed concentrations is typical for polyvinylpyrrolidone (kollidon K90F ) as abinder?
phosphates, organic acids, inorganic acids, sodium carbonates,
44. Which from the listed excipients are diluents ?
wet granulation with aqueous solution, method by fusion, extrusion, wet granulation with 96%25 ethanol,
45. Which from the listed excipients can be used as binders in the wet granulation process ?
up to 30 min, up to 5 min, up to 15 min, up to 3 min,
46. What stage is necessary to be performed after obtaining the total granule mass , before drying ?
in 200ml water medium at 37 C, in disintegration apparatus with water medium, in 200 ml water medium at 25 C, in disintegratiun apparatus with 0.1N hydrochloric acid medium,